Children with diseases affecting the nervous system often experience pain and irritability due to unknown causes. Sometimes the source of pain and irritability can be identified through careful physical examination, lab tests and imaging. Many times, however, examination reveals no obviously correctable source for pain and irritability. At that stage, various therapies are attempted to reduce pain, irritability and agitation. Unfortunately, there is no common approach to treating these problems.

Our team of researchers would like to see how useful it is for your healthcare team to use standardized clinical guidelines when treating your child. When doctors and nurses follow standardized guidelines, we sometimes call it an integrated clinical pathway. In this study children with unexplained pain and irritability follow a pathway of known tests and treatments in order to find the cause and resolve the pain.


What is this study about?

The purpose of this project is to develop, test, and disseminate a new approach to reducing and resolving pain in children with Severe Neurological Impairments (SNI). It focuses on the problem of ongoing, unexplained, and difficult-to-treat pain and irritability that many children with SNI, and their families, experience. Click here to learn more.


If your child is experiencing pain and you don't know why, you might be eligible to participate in the PIUO Study.

We are looking for children between 6 months and 18 years with neurological problems, who cannot communicate verbally about their pain and continue to have unexplained pain. The pain must not be due to accidents, injury or to medical procedures, and must not have responded to treatments in the past. Click here to learn more.


team Members

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